Addiction
Addiction is a chronic, relapsing dysfunction of the brain's reward, motivation, and memory circuitry — compulsive substance use or behavior that continues despite harmful consequences. It centers on dysregulated dopamine signaling in the mesolimbic reward pathway, with adaptations in glutamate and GABA systems.
Neurotransmitters
Related
- Ketamine (↕)(prelim)
Books (5)
Podcasts
Research (88)
- From molecular mechanisms to digital surveillance: the 2010-2025 evolution of benzodiazepine and Z-drug misuse research Liu et al. (2026) Full text ↗ PubMed ↗
- Dopamine transporter and beyond: evolving targets and combination strategies in stimulant use disorder de et al. (2026) Full text ↗ PubMed ↗
- About Sugar Addiction Guo et al. (2025) Full text ↗ PubMed ↗
- Neurotransmitter-related functional connectivity changes in serotonin and dopamine systems after mindfulness in medication overuse headache Fedeli et al. (2025) Full text ↗ PubMed ↗
- High-intensity interval training exercise decreases brain CB1 receptor levels in male and female adult rats Tyler et al. (2025) Full text ↗ PubMed ↗
- Demystifying the New Dilemma of Brain Rot in the Digital Era: A Review Yousef et al. (2025) Full text ↗ PubMed ↗
- CBD and the 5-HT1A receptor: A medicinal and pharmacological review Alexander et al. (2025) Full text ↗ PubMed ↗
- Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction Li et al. (2025) Full text ↗ PubMed ↗
- The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep Zhu et al. (2025) Full text ↗ PubMed ↗
- The Impact of Social Media & Technology on Child and Adolescent Mental Health Masri-Zada et al. (2025) Full text ↗ PubMed ↗
- GABA and its receptors' mechanisms in the treatment of insomnia Zhu et al. (2024) Full text ↗ PubMed ↗
- Childhood obesity, sugar, and Early Childhood Caries: the sweet trap Colombo et al. (2024) Full text ↗ PubMed ↗
- Gut microbiota modulates neurotransmitter and gut-brain signaling Wang et al. (2024) Full text ↗ PubMed ↗
- A neural circuit for alcohol withdrawal-induced hyperalgesia in a nondependent state Zhang et al. (2024) Full text ↗ PubMed ↗
- Adolescent stress differentially modifies dopamine and norepinephrine release in the medial prefrontal cortex of adult rats Carboni et al. (2024) Full text ↗ PubMed ↗
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