Regulation of inflammaging
☆ Watchresearch · published 2025-01-01 · by Chiappelli F, Fotovat L, Khakshooy A, Oluwadara O, Penhaskashi J
Bioinformation · 2025
Abstract
The non-neuronal cholinergic system plays an important role in the modulation of immunity and in particular the control of the inflammatory response. The cholinergic anti-inflammatory pathway is mediated principally by the α7-nicotinic acetylcholine receptor (α7-nAChR) and its receptor-specific chaperone, resistance to inhibitors of cholinesterase (RIC)-3 chaperone protein. The point is made in this writing that therapeutic stimulation of the non-neuronal cholinergic system via, for instance, transcutaneous vagal stimulation, pharmaco-therapeutic activation of α7-nAChR/RIC-3, or stimulation of the pathway by other means, including microRNA treatment interventions could down-regulate states of inflammation such as the cytokines storm and chronic systemic inflammation in aging - viz , inflammaging. It is possible and even likely that controlling inflammaging by intervening on the non-neuronal cholinergic system (NNCS) will be beneficial to a wide range of aging-related diseases, from type 2 diabetes and obesity to periodontal disease.
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Neurotransmitters
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