Enkephalins are small endogenous opioid peptides that modulate pain and emotion through delta- and mu-opioid receptors. Widely distributed in the brain, spinal cord, and gut, they dampen pain signaling and influence mood, reward, and stress. Together with endorphins and dynorphins they make up the body’s opioid peptide system.

Too little may be associated with

Increased pain

Too much may be associated with

Excessive pain suppression

Informational only — not medical advice.

Stimuli that influence it

Substances

Research (21)

Links

Recovery resources

For stimuli that influence Enkephalins. Not medical advice — see all recovery resources.