Enkephalins
Enkephalins are small endogenous opioid peptides that modulate pain and emotion through delta- and mu-opioid receptors. Widely distributed in the brain, spinal cord, and gut, they dampen pain signaling and influence mood, reward, and stress. Together with endorphins and dynorphins they make up the body’s opioid peptide system.
Too little may be associated with
Increased pain
Too much may be associated with
Excessive pain suppression
Informational only — not medical advice.
Stimuli that influence it
Substances
Research (21)
- Medications for Opioid Use Disorder, Opioid Withdrawal, and Opioid Overdose: A Review Harris et al. (2026) Full text ↗ PubMed ↗
- Biochemistry, Endorphin Chaudhry et al. (2026) PubMed ↗
- Gestational buprenorphine-naloxone exposure and fetal neurobehavior Jansson et al. (2024) Full text ↗ PubMed ↗
- Caring for Hospitalized Adults With Opioid Use Disorder in the Era of Fentanyl: A Review Englander et al. (2024) Full text ↗ PubMed ↗
- Extended-release versus oral buprenorphine as opioid maintenance treatment during pregnancy-maternal and neonatal outcomes Kanervo et al. (2024) Full text ↗ PubMed ↗
- Possible role of exercise therapy on depression: Effector neurotransmitters as key players Alizadeh (2024) Full text ↗ PubMed ↗
- Buprenorphine-Naloxone Maintenance and Lactation Jansson et al. (2024) Full text ↗ PubMed ↗
- Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot Study Kharasch et al. (2023) Full text ↗ PubMed ↗
- Neurochemistry of the mammillary body Żakowski et al. (2023) Full text ↗ PubMed ↗
- Treatment of Kratom Withdrawal and Dependence With Buprenorphine/Naloxone: A Case Series and Systematic Literature Review Weiss et al. (2021) Full text ↗ PubMed ↗
- Methadone for Pain Management: A Pharmacotherapeutic Review Kreutzwiser et al. (2020) Full text ↗ PubMed ↗
- Medication Treatment of Opioid Use Disorder Bell et al. (2020) Full text ↗ PubMed ↗
- Opioids for cancer pain - an overview of Cochrane reviews Wiffen et al. (2017) Full text ↗ PubMed ↗
- Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient Pan et al. (2017) Full text ↗ PubMed ↗
- Addiction disorders Merrill et al. (2014) Full text ↗ PubMed ↗
Links
Recovery resources
For stimuli that influence Enkephalins. Not medical advice — see all recovery resources.
SMART Recovery · general recovery
Narcotics Anonymous (NA) · substance abuse