Nitric Oxide (NO)
⤢ 3D
Nitric oxide is an unusual gaseous signaling molecule that diffuses freely across membranes rather than acting at classical receptors. In blood vessels it drives relaxation and increased blood flow (including in the brain and during erection), and in the nervous system it acts as a retrograde messenger supporting synaptic plasticity and learning. It also contributes to immune defense.
Too little may be associated with
Vascular dysfunction
Too much may be associated with
Neurotoxicity, inflammation
Informational only — not medical advice.
Stimuli that influence it
Functions
Books (2)
Research (25)
- Nitric Oxide-Mediated Minimally Invasive Neuromodulation through Gut-Brain Axis via a Bioelectronic Microdevice for Relieving Depressive Symptoms Zhang et al. (2026) Full text ↗ PubMed ↗
- Hypothalamic Dysfunction Casipit et al. (2026) PubMed ↗
- Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure Fontes et al. (2025) Full text ↗ PubMed ↗
- Mucuna pruriens, a Possible Treatment for Depressive Disorders Mata-Bermudez et al. (2024) Full text ↗ PubMed ↗
- Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats Abdel-Rahman et al. (2024) Full text ↗ PubMed ↗
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study Majeed et al. (2023) Full text ↗ PubMed ↗
- Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs Cirino et al. (2023) Full text ↗ PubMed ↗
- Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy Essawy et al. (2022) Full text ↗ PubMed ↗
- Revisiting the role of neurotransmitters in epilepsy: An updated review Angelopoulou et al. (2021) Full text ↗ PubMed ↗
- Nitric Oxide Signaling in the Auditory Pathway Kopp-Scheinpflug et al. (2021) Full text ↗ PubMed ↗
- Role of Herbal Medicines in the Management of Brain Injury Safdari et al. (2021) Full text ↗ PubMed ↗
- Sudden Cardiac Death in Anabolic-Androgenic Steroid Users: A Literature Review Amico et al. (2020) PubMed ↗
- Allergic Endotypes and Phenotypes of Asthma Phipatanakul et al. (2020) Full text ↗ PubMed ↗
- Natural Products with Antiplatelet Action Hirsch et al. (2017) Full text ↗ PubMed ↗
- 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016 Liu et al. (2016) Full text ↗ PubMed ↗