Cannabis / Marijuana / THC(HARMFUL)
Cannabis and its main intoxicant THC act on the endocannabinoid system. Moderate-quality evidence supports use for chronic and neuropathic pain, chemotherapy-induced nausea, and multiple-sclerosis spasticity, and it is widely used recreationally for its psychoactive effects. Risks include dependence, impaired memory and attention while intoxicated, and — particularly with frequent, high-THC use in adolescence — increased risk of psychosis and cannabis use disorder.
Too little may be associated with
No requirement.
Too much may be associated with
Dependence, anxiety, cognitive and motivational effects.
Informational only — not medical advice.
Neurotransmitters
Books (5)
Research (13)
- Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy Roalf et al. (2026) Full text ↗ PubMed ↗
- Schizophrenia Leucht et al. (2025) Full text ↗ PubMed ↗
- Sex- and age-specific respiratory alterations induced by prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 in rats Gargaglioni et al. (2023) Full text ↗ PubMed ↗
- Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity Rosenberg et al. (2023) Full text ↗ PubMed ↗
- Functional interactions between cannabinoids, omega-3 fatty acids, and peroxisome proliferator-activated receptors: Implications for mental health pharmacotherapies Jung et al. (2022) Full text ↗ PubMed ↗
- Schizophrenia Jauhar et al. (2022) Full text ↗ PubMed ↗
- The Pharmacological Case for Cannabigerol Nachnani et al. (2021) Full text ↗ PubMed ↗
- Warfarin and food, herbal or dietary supplement interactions: A systematic review Tan et al. (2021) PubMed ↗
- The Neuroscience of Drug Reward and Addiction Volkow et al. (2019) Full text ↗ PubMed ↗
- Cannabis Addiction and the Brain: a Review Volkow et al. (2018) Full text ↗ PubMed ↗
- Cannabis, Cannabinoids, and Sleep: a Review of the Literature Babson et al. (2017) Full text ↗ PubMed ↗
- The dopamine theory of addiction: 40 years of highs and lows Nutt et al. (2015) Full text ↗ PubMed ↗
- Cannabidiol--recent advances Mechoulam et al. (2007) Full text ↗ PubMed ↗
Links
Recovery resources
Help for cannabis / marijuana / thc use and recovery. Not an endorsement or medical advice — see all recovery resources.
SAMHSA National Helpline (US)
A free, confidential, 24/7 US treatment-referral and information line for individuals and families facing substance use or mental health disorders.
Co-Anon Family Groups
Support for the families and friends of someone with a cocaine or other drug problem.
Families Anonymous (FA)
A 12-step fellowship for the relatives and friends of people affected by drug abuse or related behavioral problems.
Nar-Anon Family Groups
A 12-step program for the families and friends of people addicted to drugs.
Dual Recovery Anonymous (DRA)
A 12-step fellowship for people managing both a substance addiction and a co-occurring mental illness.
- Marijuana Anonymous (MA)
A 12-step fellowship for people who want to stop using marijuana.
Narcotics Anonymous (NA)
A global 12-step fellowship for people recovering from addiction to any drug.
SMART Recovery
A secular, science-based recovery program using cognitive-behavioral tools for any addictive behavior.
Community
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