C5H9N3
⤢ 3D

Histamine is best known for allergy and inflammation, but in the brain it is a neurotransmitter that promotes wakefulness and arousal. Neurons of the tuberomammillary nucleus release it to sustain alertness — which is why antihistamines that cross into the brain cause drowsiness. It also influences appetite, learning, and the body’s immune and gastric-acid responses.

Too little may be associated with

Excessive sleepiness

Too much may be associated with

Allergic symptoms, insomnia

Informational only — not medical advice.

Stimuli that influence it

Functions

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Research (29)

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